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KMID : 1134820070360101263
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Journal of the Korean Society of Food Science and Nutrition
2007 Volume.36 No. 10 p.1263 ~ p.1270
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Anti?atherogenic Effect of Green Tea Product through Hypolipidemic and Anti?oxidative Action in Ovariectomized Rats
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Cho Mi-Kyung
Noh Kyung-Hee
Song Young-Sun
Kim Jin-Ju
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Abstract
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This study was carried out to investigate the effect of green tea product (GTP) on the risk factors of atherosclerosis in ovariectomized (OVX) rats. Sprague-Dewley female rats (10 weeks) weighing approximately 279±2 g were divided into 4 groups: sham operated control group treated with high cholesterol diet (Sham-C), OVX control group treated with high cholesterol diet (OVX-C), OVX-G 5% group treated with high cholesterol containing 5% GTP and OVX-G 20% group treated with high cholesterol diet containing 20% GTP. Serum TG concentrations was lower in OVX-G 20% group than in the OVX-C group, whereas ratio of HDL-cholesterol to total cholesterol (%) was significantly (p＜0.05) increased in the 20% GTP supplementation group than in the Sham-C and OVX-C groups. Tumor necrosis factor-α levels were significantly (p＜0.05) decreased in the OVX-G 20% group. Hepatic TG levels were significantly (p＜0.05) lowered in OVX-G 20% group than in the other groups. Glutathione levels and antioxidant enzyme activities including glutathione-reductase and Mn-superoxide dismutase in liver were significantly (p＜0.05) higher in the OVX-G 20% group in the OVX-C group. Fecal total cholesterol concentrations were increased in the GTP supplementation groups than in the OVX-C group. From the above results, it is concluded that GTP may reduce the risk of atherosclerosis via hypolipidemic action. Therefore, it may be used to possibly improve the hyperlipemia in menopausal women.
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KEYWORD
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green tea product, ovariectomized rats, anti-atherogenic effect, hypolipodemic and anti-oxidative actions
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